生物与制药工程学院教师个人简历

个人成就及成果：

(1) Jiaxing Zhao, Bing Zhang, Qing Mao, Kunqi Ping, Peng Zhang, Fengwei Lin, Dan Liu, Yao Feng, Ming Sun, Yan Zhang, Qiu Hua Li, Tingjian Zhang, Yanhua Mou, Shaojie Wang. Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis. J Med Chem，2022，65(6): 4926-4948.

(2) Jiaxing Zhao, Qing Mao, Fengwei Lin, Bing Zhang, Ming Sun, Tingjian Zhang, Shaojie Wang. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem，2022，229: 114086.

(3) Ming Sun, Jiaxing Zhao, Qing Mao, Chengda Yan, Bing Zhang, Yuwei Yang, Xiwen Dai, Jun Gao, Fengwei Lin, Yulin Duan, Tingjian Zhang, Shaojie Wang. Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site. Bioorg Med Chem, 2021, 38:116117.

(4) Zixin Yang, Jiaxing Zhao, Yao Feng, Yu Lei, Dan Liu, Feng Qin, Jiang Zheng, Shaojie Wang. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. J Pharm Biomed Anal, 2020, 190: 113497.

(5) Qingmei Li, Wei Li, Jiaxing Zhao, Xiucai Guo, Qian Zhou, Zixin Yang, Ruixue Tian, Ying Peng, Jiang Zheng. Glutathione Conjugation and Protein Adduction by Environmental Pollutant 2,4-Dichlorophenol In Vitro and In Vivo. Chem Res Toxicol, 2020, 33(9): 2351-2360.

(6) 结肠靶向前药及药物递送系统的制备方法和用途（专利号：CN 115806554 A，发明人：王绍杰，赵佳星，刘丹）

(7) 抑制黄嘌呤氧化酶活性的嘧啶并吡啶类衍生物及制备方法和应用（专利号：CN 112778318 B，发明人：王绍杰，赵佳星，段雨琳，杨玉威，毛青）

(8) 2-(3-氰基-4-烷氧基)苯基嘧啶衍生物及其制备方法和用途（专利号：CN 112209886 A，发明人：王绍杰（导师），毛青，赵佳星）

(9) 一种抑制黄嘌呤氧化酶活性的化合物及制备方法和应用（专利号：CN 113004208 A，发明人：王绍杰，赵佳星，杨玉威，段雨琳，毛青）

(10) 2-苯基嘧啶甲酸衍生物及其制备方法和应用（专利号：CN 112979559 A，发明人：王绍杰，赵佳星，毛青，杨玉威，段雨琳）

(11) 作为LPAR1拮抗剂的化合物、其药物组合物和用途（申请号：CN 202310941613.4，发明人：赵佳星，娄军，卢晓琴，曾晶）

(12) 作为LPAR1拮抗剂的化合物、其药物组合物和用途（申请号：CN 202410173619.6，发明人：娄军，赵佳星，卢晓琴，曾晶）