生物与制药工程学院教师个人简历

个人成就及成果：

李宇兴，男，1991年生，中共党员，博士，讲师。2023年获哈尔滨工业大学生物医学工程博士学位，主要从事B淋巴细胞发育和体液免疫应答分子调控方面研究，在Nature Communications、Cell Reports、The Journal of Immunology等本领域重要学术期刊上发表SCI论文7篇。参与完成广东省自然科学基金、深圳市自然科学基金各一项。

近年来代表性论文（Representative Publications）:

1. Li Y, Ruan GX, Chen W, Huang H, Zhang R, Wang J, Li Y, Xu S, Ou X: RNA-Editing Enzyme ADAR1 p150 Isoform Is Critical for Germinal Center B Cell Response. J Immunol 2022 209(6): 1071-1082.

2. Li Y, Ruan GX, Chen W, Huang H, Zhang R, Wang J, Ouyang Y, Zhu Z, Meng L, Wang R, et al.: The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation. FEBS Lett 2023, 597:1748-1760.

3. Huang H, Li Y, Zhang G, Ruan GX, Zhu Z, Chen W, Zou J, Zhang R, Wang J, Ouyang Y, et al.: The RNA-binding protein hnRNP F is required for the germinal center B cell response. Nat Commun 2023, 14:1731.

4. Chen W, Li Y, Ruan G-X, Huang H, Zhang R, Wang J, Ouyang Y, Li Y, Xu S, Ou X: Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis. Cell Reports 2022, 41(8): 46303.

5. Ruan G-X, Li Y, Chen W, Huang H, Zhang R, Chen C, Lam K-P, Xu S, Ou X: The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. Cell Reports 2022, 38(6): 110338.

6. Zhang R, Wang D, Ruan GX, Wang R, Li Y, Chen W, Huang H, Wang J, Meng L, Zhu Z, et al.: Spliceosome component PHD finger 5A is essential for early B lymphopoiesis. Development 2024, 151.

7. Pan J, Huang X, Li Y, Li M, Yao N, Zhou Z, Li X: Zinc protects against cadmium-induced toxicity by regulating oxidative stress, ions homeostasis and protein synthesis. Chemosphere 2017, 188:265-273.